This is a recent and exciting news about colon cancer. Scientists
and researchers have discovered a gene that, when it stops
working, causes the appearance of colon cancer in its sporadic (noninherited)
form. This discovery is predicted to create new treatments and new
ways of preventing colon cancer. These researchers found out that
this particular gene can be activated again by a special medicine.
This research reconfirms that this gene, called hMLH1, has a major
importance in the fight against colon cancer.
Scientists know that if gene isn't working properly it will
come to the development of a type of colon cancer found at people
that have no family history. But when it works correctly it stops
the DNA from the cells from getting damaged. It does this by
producing an enzyme that detects mistakes in the DNA fixing them
before the whole cell is corrupted.
If the gene deactivates, the DNA gets tainted with methylation,
a substance that makes the cell reproduce itself chaotically
producing malformed cells. There is a drug known as 5-azacytide
that separates the methylation of the DNA and repairs the cell.
But scientists can't use this drug and they already look for a new
one because 5-azacytide is very toxic. This fact was discovered by
analyzing several colon cancer patients. At all of them colon
cancer started while the age of 50 or 60, just the average time of
this kind of cancer.
It is proven that the hMLH1 gene is inactive at colon cancer
patients and it's already known how to activate it again and make
it work properly. After activation of this gene patients become
more receptive to chemotherapy, this way increasing the chances of
destroying the colon tumors they have.
There may be a way of preventing the development of the cancer,
if the DNA of the cell can be protected as soon as the gene starts
to deactivate. This can be done. Researchers must find a way to
isolate the gene and then modify it in such a way it won't shut
down.
This news is exciting but it takes lots of further research and
technological breakthrough to make it work at the practical level
before doctors can apply this technology to prevent and cure colon
cancer.
If you have questions related to this article you may e-mail me
at doctor@soontongkiong.com quoting the contents of the article.
About the author
DR SOON is a medical practitioner. He holds four degrees. MBBS
(University of Malaya), MBA (University of East Asia), LLB (Hons)
(University of Wolverhampton), Master of Medicine (Edith Cowan
University).
:
Dr SOON is the owner of AskMyVisitor.com and MyScriptDoctor.com
where you can find the most up-to-date advice and information
on
many medical, health and lifestyle topics.